screening

Screening is the process of screening out a population to select the target product. Screening in drug discovery refers to the process of finding substances that have the effect of ameliorating diseases from a group of drug candidates or selecting the substances that show the suitable efficacy. There are several concepts and methods for screening, which are used in the process of creating new drugs. Some examples are: Target-based screening where a substance that binds to specific targets (proteins and genes) that cause disease and inhibits or activates their functions is selected, phenotypic screening which selects the substance that changes the characteristics of the disease in a model cell where disease characteristics is reproduced; and high throughput screening (HTS) that quickly selects the one with desired effect from a large population of thousands to millions of drug candidates.

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